Key result
The END-1 gene lys-198 asn polymorphism in a homozygous state was associated with a high risk of an unsatisfactory condition of permanent vascular access (p=0.019).
Why the study?
Vascular access dysfunction in patients on programmed haemodialysis often occurs without apparent reason, prompting investigation into additional factors such as genetic predictors.
Do specific genetic polymorphisms affect the functioning of permanent vascular access in patients on dialysis?
Observational
Do specific genetic polymorphisms affect the functioning of permanent vascular access in patients on dialysis?
p-value: p=0.019
Specific genetic polymorphisms, particularly in the END-1 and SOD-2 genes, are associated with an increased risk of permanent vascular access dysfunction in dialysis patients.
Does not warrant genetic testing for vascular access planning; leaves open the role of END-1 polymorphism in dialysis access outcomes.
Thromboses and stenoses of permanent vascular access appear to be a serious hazard for patients with end-stage kidney disease on programmed haemodialysis. Relapses of these pathological conditions are the cause of repeated hospitalization, secondary surgical interventions and may eventually lead to impossibility of carrying out procedures of haemodialysis. Often, vascular access dysfunction occurs for no apparent reason, thus underlying the importance of studies aimed at revealing additional factors of intravascular thrombogenesis and neointimal formation in a vascular access, including the works dedicated to studying genetic predictors of the development of the above-mentioned complications. The authors examined herein the role of polymorphisms of the genes of endothelin-1 (END-1), nitric oxide synthase-3 (NOS-3), angiotensinogen-2 (AGT-2), angiotensinogen-1 (AGT-1), angiotensinogen 2 receptor type 1 (AGTR1), mitochondrial superoxide dismutase-2 (SOD-2), catalase (CAT) superoxide dismutase-1 (SOD-1) and angiotensin converting enzyme (ACE) in the functional state of permanent vascular access in patients on dialysis. The obtained results demonstrated direct cause-and-effect relationships between polymorphisms lys-198 asn in the END-1 gene, C60T, T58C in the SOD-2 gene and the function of vascular access. The presence of END-1 gene lys-198 asn polymorphism in a homozygous state (allele 1) was associated with a high risk of an unsatisfactory condition of permanent vascular access (p=0.019).
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Kalinin et al. (2019) conducted an observational in End-stage kidney disease on programmed haemodialysis. END-1 gene lys-198 asn polymorphism in a homozygous state was evaluated on Unsatisfactory condition of permanent vascular access (p=0.019). The END-1 gene lys-198 asn polymorphism in a homozygous state was associated with a high risk of an unsatisfactory condition of permanent vascular access (p=0.019).
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