Key result
In healthy volunteers, Doppler diastolic parameters were similar between sexes, but E wave and e' decreased progressively with age, highlighting the need for age-specific reference values.
Population
449 healthy volunteers (198 men and 251 women), mean age 45.8 ± 13.7 years
Design
Cross-sectional
Authors
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Supports age-specific Doppler norms for diastolic assessment; leaves open prospective validation against outcomes.
Cross-Sectional (n=449)
Yes
The NORRE study provides age- and gender-specific normal reference ranges for cardiac Doppler parameters, highlighting the need for age-specific cut-offs in evaluating LV diastolic function.
Caballero et al. (2015) conducted a cross-sectional in Healthy volunteers (n=449). Age and gender was evaluated on Normal reference ranges for Doppler parameters. In healthy volunteers, Doppler diastolic parameters were similar between sexes, but E wave and e' decreased progressively with age, highlighting the need for age-specific reference values.
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