Why the study?
Do large initial doses of amiodarone shorten the time to achieve control of refractory ventricular arrhythmias compared to a lower-dose regimen?
Population
Patients with ventricular arrhythmias refractory to conventional therapy
Comparison
Large initial doses of amiodarone vs Lower-dose regimen of amiodarone
Design
Cohort
Authors
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Higher initial amiodarone doses were associated with faster partial control; leaves open optimal dosing pending randomized trials.
Do large initial doses of amiodarone shorten the time to achieve control of refractory ventricular arrhythmias compared to a lower-dose regimen?
Higher initial doses of amiodarone shorten the time to achieve control of refractory ventricular arrhythmias without increasing serious side effects.
Louis Rakita (1983) studied this question.
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