Key result
This review examines myocardial triacylglycerol turnover and evaluates whether its accumulation protects against fatty acid-induced lipotoxicity or acts as a maladaptive response driving dysfunction.
This review highlights the complex role of myocardial triacylglycerol turnover in diabetic cardiomyopathy, exploring whether lipid accumulation is protective or maladaptive.
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Should not alter diabetic cardiomyopathy management; leaves open whether myocardial triacylglycerol accumulation is protective or maladaptive.
Brindley et al. (2010) conducted a review in Myocardial lipotoxicity and diabetic cardiomyopathy. Fatty acid storage and mobilization was evaluated. This review examines myocardial triacylglycerol turnover and evaluates whether its accumulation protects against fatty acid-induced lipotoxicity or acts as a maladaptive response driving dysfunction.
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