Key result
Admission after 2015 stroke guidelines linked to ~2-point lower in-hospital stroke recurrence.
Why the study?
Acute ischaemic stroke carries a high risk of early recurrence, but the clinical characteristics and risk factors of in-hospital recurrence across different time periods needed assessment.
What are the clinical characteristics and risk factors of in-hospital ischaemic recurrence in acute ischaemic stroke patients over different periods?
Observational (n=2,025)
No
What are the clinical characteristics and risk factors of in-hospital ischaemic recurrence in acute ischaemic stroke patients over different periods?
The rate of in-hospital ischaemic recurrence in acute ischaemic stroke patients has decreased over time, though infection and diabetes remain significant risk factors.
Answers are grounded in this paper and cite their sources.
Temporal reduction in recurrence supports evolving stroke care; leaves open causality and specific interventions in observational data.
Acute ischaemic stroke (AIS) has a high risk of recurrence, particularly in the early stage. Our study aimed to assess the clinical characteristics and risk factors of in-hospital ischaemic recurrence in AIS patients in different periods. This study was a retrospective, single-center analysis. The patients were divided into two stages based on their admission time. The primary endpoint was recurrent stroke during hospitalization. In total, 978 patients in Stage 1 and 1047 patients in Stage 2 were included in this study. The in-hospital recurrence rate in Stage 1 was 5.9%, while that in Stage 2 was 4.0% (p = 0.046). A recurrence rate reduction mainly occurred in the minor stroke and large-artery atherosclerosis (LAA) stroke patients. Infection was an independent risk factor despite amelioration by antiplatelet therapy (p < 0.001). Diabetes patients also had a higher risk of in-hospital ischaemic recurrence among the minor stroke and large-artery atherosclerosis patients. A positive attitude towards antiplatelet therapy failed to completely halt recurrence of the disease. In conclusion, the rate of in-hospital ischaemic recurrence in AIS patients showed a decreasing trend over time, especially in the minor stroke and large-artery atherosclerosis stroke patients. Infection and diabetes were associated with a higher risk of stroke recurrence.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2022) conducted an observational in Acute ischaemic stroke (n=2,025). Admission in Stage 2 (January 2016 to December 2017, post-2015 Chinese AIS guidelines) vs. Admission in Stage 1 (January 2014 to December 2015) was evaluated on Recurrent ischaemic stroke during hospitalization (p=0.046). Admission in 2016-2017 after the 2015 stroke guideline update was associated with a lower in-hospital stroke recurrence rate of 4.0% compared to 5.9% in 2014-2015.
Synapse has enriched 10 related papers. Consider them for comparative context: