Provides a basic physiological overview of how renin synthesis is regulated by systemic factors and intracellular messengers like cAMP, NO, and calcium.
Does not support practice changes in renin-angiotensin therapies; leaves open targeted modulation of juxtaglomerular signaling for future study.
Renin synthesis in vivo is feedback regulated by the plasma angiotensin II concentration, the intrarenal pressure, the salt loading of the organism and the macula densa mechanism. At the level of renal juxtaglomerular cells renin synthesis is regulated by cyclic AMP, by nitric oxide and by the cytosolic calcium concentration. Cyclic AMP and nitric oxide are stimulators, whereas calcium is an inhibitor of renin synthesis.
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Bruna et al. (1996) studied this question.
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