January 1, 1990Cells Tissues Organs

Influence of Pretreatment on Interstitial and Intracellular Space of Canine Left-Ventricular Myocardium

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Population

Canine left-ventricular myocardium samples

Comparison

Pretreatment conditions and fixation methods vs Comparison between different pretreatment and…

Design

Preclinical

Authors

ASAndreas SchmiedlMedizinische Hochschule Hannover PSPh. A. SchnabelHeidelberg University GHG. HaasisUniversity of Göttingen

Discussion

Member takes

Implication

HTK arrest may enhance myocyte preservation in canine models; leaves open translation to clinical cardioplegia.

Structured PICO

Population

Canine left-ventricular myocardium samples

Intervention

Pretreatment conditions (beating, fibrillating, cardioplegically HTK-arrested) and fixation methods (immersion or perfusion)

Comparator

Comparison between different pretreatment and fixation methods

Outcome

Qualitative and morphometric evaluation of interstitial space and myocytessurrogate

Pretreatment and fixation methods significantly affect the structural evaluation of myocytes and interstitium in canine myocardium, with HTK-arrest providing better cellular preservation.

Cite This Study

Schmiedl et al. (1990) studied this question.

synapsesocial.com/papers/6a7d98e0629c956ef7ac7b1a https://doi.org/10.1159/000146935

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