Key result
A new method using direct electrical current yielded an extracellular space of 51% in canine Purkinje strands and 23.3% in cat papillary muscles, and detected volume changes with osmotic stress.
Population
21 canine cardiac Purkinje strands and 4 cat papillary muscles
Design
Preclinical
Authors
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May aid studies of cardiac volume regulation in isolated preparations; leaves open in vivo and clinical validation.
A novel electrical method accurately measures extracellular space and cell volume in isolated cardiac muscle preparations, which may be useful for studying volume abnormalities in disease states.
Houser et al. (1979) studied Isolated cardiac muscle (n=25). Direct electrical current method for volumetric measurements was evaluated on Extracellular space and cell volume. A new method using direct electrical current yielded an extracellular space of 51% in canine Purkinje strands and 23.3% in cat papillary muscles, and detected volume changes with osmotic stress.
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