What does this research mean for the field?

Short canine Purkinje strands function as simple finite one-dimensional cables with small extracellular series resistance and wide extracellular clefts, enabling highly homogeneous voltage-clamp measurements of cardiac currents. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 22, 1983Proceedings of the Royal Society of London. Series B, Biological sciences

Voltage-clamp studies on the canine Purkinje strand

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Population

Purkinje strands excised from the left and right ventricles of adult mongrel dogs, cut to lengths of less…

Design

Preclinical

Authors

ICIra S. CohenThomas Jefferson University RFR T FalkState University of New York RKRichard KlineCalgary Laboratory Services

Discussion

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Implication

Validates one-dimensional cable modeling for canine Purkinje strands; leaves open translation to human pacemaker currents.

Structured PICO

Population

Purkinje strands excised from the left and right ventricles of adult mongrel dogs, cut to lengths of less than 2.0 mm

Intervention

Two-microelectrodes voltage-clamp technique

Outcome

Electrophysiological properties including length constant, capacity transient, K+ depletion current, and pacemaker current reversal potentialsurrogate

Canine Purkinje strands can be treated as simple finite one-dimensional cables with wide extracellular clefts that do not affect the pacemaker current reversal potential.

Cite This Study

Cohen et al. (1983) studied this question.

synapsesocial.com/papers/6a1bf8811567d2fc4d5f5935 https://doi.org/10.1098/rspb.1983.0007

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Voltage-clamp studies on the canine Purkinje strand

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage-clamp studies on the canine Purkinje strand

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider