Regulation of brain renin-angiotensin system by benzamil-blockable sodium channels

View Full Paper

Ask AI

Bookmark

Why the study?

Does benzamil alter brain RAS mRNA expression in hypertensive rats?

Population

Rats (DOCA-salt or renal hypertensive rats)

Design

Preclinical

Follow-up

7 days

Authors

Discussion

Benzamil may modulate brain RAS in DOCA-salt hypertension; leaves open differential mechanisms across models and any human relevance.

Does benzamil alter brain RAS mRNA expression in hypertensive rats?

Population

Rats (DOCA-salt or renal hypertensive rats)

Intervention

Benzamil (blocker of amiloride-sensitive sodium channels) infused intracerebroventricularly or intravenously for 7 days

Outcome

Changes in renin-angiotensin system (RAS) mRNAs (renin, ACE, ANG II type 1 receptor) in the brain and kidneysurrogate

Benzamil-blockable brain sodium channels may participate in the regulation of brain RAS mRNAs in DOCA-salt hypertensive rats.

Nishimura et al. (1999) studied this question.

View Full Paper

Ask AI

Bookmark