NT-proBNP in the very old population: reference values and heart failure specificity from the AugUR-study

Figures

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  Fig. 1. Overview of AugUR study recruitment

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  Fig. 2. NT-proBNP values stratified for sex and age. Values of NT-proBNP in 2304 participants of the AugUR study. A box represents the lower (25%) and upper (75%) quartiles, with the median as a horizontal line within the box. The Y-axis shows NT-proBNP values on a log 10-based scale. Values marked with circles are within the 3rd interquartile range (IQR), and values marked with stars are above the 3rd IQR. Maximum NT-proBNP value: 30,122.0 pg/mL; minimum value: 9.5 pg/mL

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  Fig. 3. Percentile curves in the whole study cohort divided in eGFR < 60 mL/min/1.73 m2 (A n = 699) and eGFR ≥ 60 mL/min/1.73 m2 (B n = 1591). Y-axis shows NT-proBNP values on a log 10-based scale. Dashed line: cut-off value 125 pg/mL; light blue: 2.5–5th percentile or 95–97.5th percentile; medium blue: 5–25th percentile or 75–95th percentile; dark blue: 25–50th percentile or 50–75th percentile; solid black line: median

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  Fig. 4. Percentile curves in “GP-healthy” subjects (subgroup II) divided in men (B n = 261) and women (A n = 388). Y-axis shows NT-proBNP values on a log 10-based scale. Dashed line: cut-off value 125 pg/mL; light blue: 2.5–5th percentile or 95–97.5th percentile; medium blue: 5–25th percentile or 75–95th percentile; dark blue: 25–50th percentile or 50–75th percentile; solid black line: median

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  Fig. 5. Proportion above and below the NT-proBNP cut-off value 125 pg/mL in different subgroups. Without cardiovascular risk factors: subjects free of diabetes, obesity (BMI < 30 kg/m2), controlled blood pressure at study visit (< 160/100 mmHg). GP-healthy: additionally with normal renal function (eGFR ≥ 60 mL/min/1.73 m2) and regular heart rhythm, free of previous cardiovascular disease (stent, bypass graft, myocardial infarction); no intake of high-ceiling diuretics, NOAC, or vitamin K antagonists. Echo-healthy: additionally free of left ventricular hypertrophy (left ventricular mass to body surface area ≤ 95 g/m2 for women/≤ 115 g/m2 for men) and free of left atrial enlargement (left atrial volume/body surface area ≤ 34 mL/m.2) with normal left ventricular filling pressure (E/e′ ratio ≤ 14) and systolic function (EF ≥ 50%)