Key result
NT-proBNP measurement effectively predicted major adverse cardiac events across age groups (AUC 0.79 to 0.83), although specificity was slightly lower in patients aged 75 years and older.
Why the study?
Does NT-proBNP measurement accurately predict major adverse cardiac events across different age groups in hospitalized patients?
Cohort (n=2,224)
No
Does NT-proBNP measurement accurately predict major adverse cardiac events across different age groups in hospitalized patients?
NT-proBNP is a useful predictor of MACE across all age groups in hospitalized patients, though normal reference values are significantly higher than in community settings and specificity decreases slightly in the elderly.
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Supports NT-proBNP for MACE stratification across ages in hospitalized patients; leaves open age-specific thresholds for prospective validation.
Nielsen et al. (2004) conducted a cohort in Hospitalized patients (n=2,224). NT-proBNP measurement was evaluated on Major adverse cardiac events (MACE). NT-proBNP measurement effectively predicted major adverse cardiac events across age groups (AUC 0.79 to 0.83), although specificity was slightly lower in patients aged 75 years and older.