Key result
Laparoscopic surgery for colorectal cancer showed no statistically significant difference in postoperative venous thromboembolism compared to open surgery (OR 0.64; 95% CI 0.33-1.23; P=0.18).
Why the study?
Does laparoscopic surgery reduce postoperative venous thromboembolism in patients with colorectal cancer compared to open surgery?
Meta-Analysis (n=3,058)
Does laparoscopic surgery reduce postoperative venous thromboembolism in patients with colorectal cancer compared to open surgery?
Odds Ratio: 0.64 (95% CI 0.33–1.23)
p-value: p=0.18
Laparoscopic surgery for colorectal cancer is associated with a similar incidence of postoperative venous thromboembolism compared to conventional open surgery.
Similar postoperative VTE rates with laparoscopic versus open colorectal cancer surgery; confirms comparable safety for minimally invasive resection.
The objective of this study was to systematically compare the incidence of postoperative venous thromboembolism (VTE; deep vein thrombosis and/or pulmonary embolism) in patients with colorectal cancer after laparoscopic surgery and conventional open surgery. A systematic search of Medline, EMBASE, and the Cochrane Central Register of Controlled Trials was conducted. Eleven randomized control trials involving 3058 individuals who reported VTE outcomes were identified, of whom 1677 were treated with laparoscopic therapy and 1381 underwent open surgery. The combined results of the individual trials showed no statistically significant difference in the odds ratio for overall VTE (odds ratio 0.64, 95% confidence interval, 0.33-1.23, P=0.18), as well as in subgroups of deep vein thrombosis and anticoagulant prophylaxis between these 2 approaches. In conclusion, laparoscopic resection could achieve similar outcomes in terms of the incidence of VTE, which are associated with long-term benefits of the patients.
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Cui et al. (2013) conducted a meta-analysis in Colorectal cancer (n=3,058). Laparoscopic surgery vs. Conventional open surgery was evaluated on Postoperative venous thromboembolism (deep vein thrombosis and/or pulmonary embolism) (OR 0.64, 95% CI 0.33-1.23, p=0.18). Laparoscopic surgery for colorectal cancer showed no statistically significant difference in postoperative venous thromboembolism compared to open surgery (OR 0.64; 95% CI 0.33-1.23; P=0.18).
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