Why the study?
Does concomitant use of antifungal agents increase the risk of overanticoagulation in patients taking coumarin anticoagulants?
Does concomitant use of antifungal agents increase the risk of overanticoagulation in patients taking coumarin anticoagulants?
Concomitant use of oral miconazole and coumarin anticoagulants is associated with a profoundly increased risk of severe overanticoagulation (INR ≥ 6.0) and should be discouraged.
No takes yet. Share an insight, caveat, or question.
Oral miconazole co-use was associated with profoundly elevated overanticoagulation risk; supports avoidance but leaves open prospective confirmation of causality.
Visser et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: