Key result
The PPARGC1A Gly allele was significantly associated with athletic ability and sports performance (OR 1.13; 95% CI 1.03-1.25; P=0.01), particularly in power sports and Caucasian populations.
Why the study?
Variable results from genetic association studies warranted a meta-analysis to obtain more precise estimates of the association between the PPARGC1A Gly482Ser polymorphism and athletic ability or sports performance.
Is the PPARGC1A Gly482Ser polymorphism associated with athletic ability and sports performance?
Meta-Analysis
Is the PPARGC1A Gly482Ser polymorphism associated with athletic ability and sports performance?
Odds Ratio: 1.13 (95% CI 1.03–1.25)
p-value: p=0.01
The PPARGC1A Gly allele is significantly associated with athletic ability and sports performance, particularly in power and endurance activities among Caucasians.
No takes yet. Share an insight, caveat, or question.
Should not guide genetic testing or selection in athletes; extends candidate-gene evidence but remains hypothesis-generating.
Tharabenjasin et al. (2019) conducted a meta-analysis in Athletic ability and sports performance. PPARGC1A Gly482Ser polymorphism (Gly allele) vs. Sedentary controls was evaluated on Athletic ability and sports performance (OR 1.13, 95% CI 1.03-1.25, p=0.01). The PPARGC1A Gly allele was significantly associated with athletic ability and sports performance (OR 1.13; 95% CI 1.03-1.25; P=0.01), particularly in power sports and Caucasian populations.
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