Key result
Treatment with pitavastatin attenuated the development of load-induced cardiac hypertrophy and fibrosis in Dahl salt-sensitive rats on a high-salt diet.
Why the study?
Does pitavastatin attenuate cardiac hypertrophy and fibrosis in Dahl salt-sensitive rats on a high-salt diet?
Population
Dahl salt-sensitive (DS) rats fed a high-salt diet (8% NaCl) from 7 weeks of age
Comparison
Pitavastatin administered from 7 to 12 weeks of… vs Untreated DS rats on high-salt diet and DS rats…
Design
Preclinical
Follow-up
5 weeks (from 7 to 12 weeks of age)
Authors
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No immediate clinical implications; leaves open translation of statin pleiotropy to human cardiac remodeling.
Does pitavastatin attenuate cardiac hypertrophy and fibrosis in Dahl salt-sensitive rats on a high-salt diet?
Pitavastatin attenuates load-induced cardiac hypertrophy and fibrosis in a rat model, potentially through inhibition of the RhoA-ERK-SRF signaling pathway, independent of its cholesterol-lowering effects.
Saka et al. (2006) studied Hypertension, cardiac hypertrophy, and fibrosis. Pitavastatin vs. High-salt diet without pitavastatin was evaluated on Cardiac hypertrophy and fibrosis. Treatment with pitavastatin attenuated the development of load-induced cardiac hypertrophy and fibrosis in Dahl salt-sensitive rats on a high-salt diet.
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