Why the study?
Does modulation of Angiotensin II with ACE inhibitors prevent progressive renal tissue destruction in chronic renal diseases?
Population
Patients and animal models with chronic renal diseases
Design
Review
Authors
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May support ACE inhibitor use in progressive renal disease; leaves open individualized targeting amid genetic and environmental modulation.
Does modulation of Angiotensin II with ACE inhibitors prevent progressive renal tissue destruction in chronic renal diseases?
Angiotensin II plays a central role in the progressive destruction of renal tissue in chronic renal diseases, providing a pathophysiological rationale for targeted therapeutic interventions like ACE inhibitors.
Matsusaka et al. (1996) studied this question.
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