Why the study?
What is the mechanism by which ACE inhibitors provide renoprotective effects in hypertension and glomerulopathies?
Population
Patients with hypertension and pre-existing glomerulopathies and experimental animal models
Design
Review
Authors
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Mechanistic support for ACE inhibitors in renal protection; leaves open need for updated prospective validation.
What is the mechanism by which ACE inhibitors provide renoprotective effects in hypertension and glomerulopathies?
This review outlines the mechanistic rationale for using ACE inhibitors to prevent progressive glomerular injury by reducing intraglomerular pressure and Ang II-mediated damage.
Raij et al. (1989) studied this question.
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