Key result
Elevated glomerular pressure contributes to progressive kidney damage, with dietary restrictions and antihypertensive medications identified as promising interventions to slow progression.
Why the study?
Does antihypertensive therapy prevent progressive kidney damage in patients with hypertension and renal disease?
Population
Patients with hypertension and renal insufficiency, and patients with diabetes
Design
Review
Authors
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Supports targeting glomerular pressure with antihypertensives in hypertensive nephropathy; leaves open whether progression to ESRD is prevented in RCTs.
Does antihypertensive therapy prevent progressive kidney damage in patients with hypertension and renal disease?
Increased glomerular pressure contributes to glomerular injury, and interventions like ACE inhibitors or calcium channel blockers show promise in slowing progression to end-stage renal failure.
Dworkin et al. (1989) conducted a review in Hypertension and kidney disease. Antihypertensive therapy and dietary restriction was evaluated. Elevated glomerular pressure contributes to progressive kidney damage, with dietary restrictions and antihypertensive medications identified as promising interventions to slow progression.
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