Why the study?
Do interventions that attenuate glomerular capillary hypertension prevent structural injury in progressive renal disease?
Population
Animal models of progressive renal disease (e.g., remnant kidney rats, experimental diabetes)
Comparison
Therapeutic interventions that attenuate… vs Antihypertensive therapy that controls systemic…
Design
Review
Authors
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Targeting glomerular hypertension may protect against renal injury beyond systemic BP control; leaves open translation to human CKD.
Do interventions that attenuate glomerular capillary hypertension prevent structural injury in progressive renal disease?
Control of intra-glomerular hypertension, rather than just systemic blood pressure, is critical for protecting against progressive structural renal injury.
Sharon Anderson (1987) studied this question.
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