Key result
Antihypertensives reducing glomerular capillary pressure ameliorate experimental glomerular disease and prevent hemodynamic injury.
Population
Experimental models of reduced renal mass and patients with parenchymal renal disease
Design
Review
Authors
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Supports intraglomerular pressure reduction experimentally; leaves open translation to human CKD progression.
Reducing glomerular capillary pressure through systemic hypertension treatment is critical to preventing hemodynamic injury in renal disease.
Baldwin et al. (1987) conducted a review in Hypertension and Renal Diseases. Agents that reduce glomerular capillary pressure was evaluated. Treatment of systemic hypertension with agents that reduce glomerular capillary pressure ameliorates manifestations of experimental glomerular disease and prevents hemodynamic injury.
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