Influence of Antihypertensive Therapy on Development and Progression of Diabetic Glomerulopathy
Why the study?
Does antihypertensive therapy or a low-protein diet prevent microvascular damage in diabetic patients and animals?
Population
Diabetic patients and experimental animals
Design
Review
Authors
Discussion
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Implication
Animal data implicate capillary hypertension in diabetic microangiopathy; leaves open whether ACE inhibitors or protein restriction prevent complications in patients.
Structured PICO
Does antihypertensive therapy or a low-protein diet prevent microvascular damage in diabetic patients and animals?
P
Population
Diabetic patients and experimental animals
I
Intervention
Antihypertensive therapy (angiotensin I-converting enzyme inhibitor) or low-protein diet
O
Outcome
Prevention of microvascular damage in the kidney and retina
Hemodynamic adaptation leading to capillary hypertension is a key driver of diabetic microvascular disease, which can be mitigated by ACE inhibitors or dietary protein restriction in animal models.
Cite This Study
Anderson et al. (1988) studied this question.