Why the study?
Do ACE inhibitors prevent or reverse diabetic microvascular injury compared to calcium channel blockers in diabetic patients and experimental models?
Population
Experimental models and normotensive insulin and noninsulin dependent diabetic patients with microalbuminuria
Comparison
ACE inhibitors (including perindopril) vs Dihydropyridine calcium channel blockers
Design
Review
Authors
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May support ACE inhibitor preference in diabetic nephropathy; hypothesis-generating and leaves open need for randomized confirmation in normotensive patients.
Do ACE inhibitors prevent or reverse diabetic microvascular injury compared to calcium channel blockers in diabetic patients and experimental models?
ACE inhibitors appear to be the drugs of choice for preventing and treating diabetic renal disease and microvascular injury, independent of their blood pressure-lowering effects.
M. E. Cooper (1997) studied this question.
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