February 1, 1988Annual Review of Medicine
Intraglomerular Hypertension: Implications and Drug Treatment
Why the study?
Do therapeutic interventions that control glomerular capillary hypertension prevent progressive renal injury compared to therapies that only control systemic hypertension?
Population
Patients or experimental models with progressive renal disease and systemic hypertension
Comparison
Therapeutic interventions that control… vs Therapy that controls systemic but not…
Design
Review
Authors
Discussion
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Implication
Systemic BP control alone may not halt renal progression; leaves open whether intraglomerular-targeted therapies improve outcomes in trials.
Structured PICO
Do therapeutic interventions that control glomerular capillary hypertension prevent progressive renal injury compared to therapies that only control systemic hypertension?
P
Population
Patients or experimental models with progressive renal disease and systemic hypertension
I
Intervention
Therapeutic interventions that control glomerular capillary hypertension
C
Comparator
Therapy that controls systemic but not glomerular hypertension
O
Outcome
Prevention of progressive renal injury
This review highlights that antihypertensive therapy must specifically control intraglomerular hypertension to effectively prevent the progression of renal injury.
Cite This Study
Anderson et al. (1988) studied this question.