Key result
Preliminary clinical and animal studies suggest that angiotensin converting enzyme (ACE) inhibitors may delay the progression of diabetic nephropathy and preserve renal function.
Why the study?
Do ACE inhibitors preserve renal function in hypertensive and diabetic patients with renal failure?
Population
Hypertensive and diabetic patients with renal failure, and experimental animal models of diabetic…
Comparison
Angiotensin converting enzyme (ACE) inhibitors vs Calcium channel blockers (in experimental animals)
Design
Review
Authors
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May support ACE inhibitor consideration in diabetic nephropathy with hypertension; leaves open need for definitive RCTs before practice change.
Do ACE inhibitors preserve renal function in hypertensive and diabetic patients with renal failure?
ACE inhibitors may offer specific renoprotective effects in patients with diabetes and hypertension by controlling glomerular capillary hypertension.
Sharon Anderson (1990) conducted a review in Hypertension and diabetic nephropathy. Angiotensin converting enzyme (ACE) inhibitors vs. Calcium channel blockers was evaluated. Preliminary clinical and animal studies suggest that angiotensin converting enzyme (ACE) inhibitors may delay the progression of diabetic nephropathy and preserve renal function.
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