Population
Transfected Chinese hamster ovary cells
Comparison
Expression of wild-type cardiac sodium/calcium… vs Nontransfected cells
Design
Preclinical
Authors
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Does not support clinical translation; leaves open allosteric NCX activation as a research target in cardiac Ca2+ handling.
The cardiac sodium/calcium exchanger requires allosteric activation by cytosolic Ca2+ for Ca2+ efflux, which is retained briefly after Ca2+ returns to resting levels.
Chernysh et al. (2004) studied this question.
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