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July 1, 1999Blood

Marked Temperature Dependence of the Platelet Calcium Signal Induced by Human von Willebrand Factor

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Population

Human platelets

Comparison

Ristocetin-mediated binding of von Willebrand… vs Lower temperatures (20 degrees C to 25 degrees C)

Design

Preclinical

Authors

JKJohn C. KermodeJackson Memorial HospitalZQZheng QiEMElizabeth P. Milner

Discussion

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Implication

Requires physiologic temperature for vWF-induced platelet Ca2+ signaling; leaves open in vivo relevance to thrombosis.

Structured PICO

P
Population
Human platelets
I
Intervention
Ristocetin-mediated binding of von Willebrand factor (vWF) at physiological temperature (37 degrees C)
C
Comparator
Lower temperatures (20 degrees C to 25 degrees C)
O
Outcome
Intracellular free calcium concentration ([Ca2+]i)surrogate

The vWF-induced calcium signal in human platelets is highly temperature-dependent and relies on the release of arachidonic acid and its conversion to thromboxane A2.

Cite This Study

Kermode et al. (1999) studied this question.

synapsesocial.com/papers/6a7da2f01693de70af99a4dbhttps://doi.org/10.1182/blood.v94.1.199.413k14_199_207
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Aggregation on Extracellular Matrix: Effect of a Recombinant GPIb-Binding Fragment of von Willebrand Factor1993 · 25 citations
  2. 2A new generation of Ca2+ indicators with greatly improved fluorescence properties.1985 · 21,778 citations
  3. 3Porcine von Willebrand Factor Binding to Human Platelet GPIb Induces Transmembrane Calcium Influx1996 · 67 citations
  4. 4ADP evokes biphasic Ca2+ influx in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store1990 · 157 citations