Key result
In physiological calcium concentrations, von Willebrand factor showed little or no potentiation of ADP-induced platelet aggregation, indicating it probably cannot substitute for fibrinogen in vivo.
Why the study?
Does von Willebrand factor substitute for fibrinogen in supporting ADP-induced aggregation of human platelets under physiological calcium concentrations?
Population
Human platelets
Comparison
von Willebrand factor (vWf) vs Fibrinogen
Design
Preclinical
Authors
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vWF unlikely to substitute for fibrinogen in ADP-induced aggregation in vivo; leaves open its role in human platelet function and thrombosis.
Does von Willebrand factor substitute for fibrinogen in supporting ADP-induced aggregation of human platelets under physiological calcium concentrations?
von Willebrand factor likely cannot substitute for fibrinogen in supporting ADP-induced platelet aggregation in vivo, as it fails to support aggregation at physiological calcium concentrations.
Harfenist et al. (1987) studied this question. von Willebrand factor (vWf) in high vs low calcium media vs. fibrinogen was evaluated on ADP-induced aggregation of human platelets. In physiological calcium concentrations, von Willebrand factor showed little or no potentiation of ADP-induced platelet aggregation, indicating it probably cannot substitute for fibrinogen in vivo.
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