Key result
Ticagrelor pretreatment prevented most abnormalities in sodium and potassium channel currents, action potentials, and intracellular calcium in stellate ganglion neurons following MI in rabbits.
Why the study?
Higher sympathetic activity, partly mediated by stellate ganglion electrical activity, predisposes to malignant ventricular arrhythmias after myocardial infarction, but the effects of ticagrelor pretreatment on stellate ganglion neuron electrophysiology were unknown.
Does ticagrelor pretreatment prevent electrophysiological abnormalities in stellate ganglion neurons following myocardial infarction in rabbits?
Does ticagrelor pretreatment prevent electrophysiological abnormalities in stellate ganglion neurons following myocardial infarction in rabbits?
Ticagrelor pretreatment prevents electrophysiological abnormalities in stellate ganglion neurons post-MI, suggesting a potential mechanism for reducing malignant ventricular arrhythmias.
Hypothesis-generating for ticagrelor in post-MI arrhythmia prevention; requires clinical trials before practice implications.
Higher sympathetic activity predisposes to malignant ventricular arrhythmias in the context of myocardial infarction (MI). This is, in part, mediated by the electrical activity of the stellate ganglion (SG). The aim of this study is to examine the effects of ticagrelor pretreatment on the electrophysiological properties of SG neurons following MI in rabbits. MI was induced by isoproterenol (ISO) of 150 mg kg ‐1 d ‐1 (twice at an interval of 24 hours). Ticagrelor pretreatment was administered at low‐ (10 mg kg ‐1 d ‐1 ) or high‐dose (20 mg kg ‐1 d ‐1 ). Protein and RNA expression were determined by immunohistochemical analysis and real‐time PCR, respectively. The activity of sodium channel current ( I Na ), delayed rectifier potassium current ( I KDR ), M‐type potassium current ( I KM ) as well as action potentials (APs) from SG neurons were measured by whole‐cell patch‐clamp. Intracellular calcium concentrations were measured by confocal microscopy. Compared with the control group, the MI group exhibited a greater amplitude of I Na , I KDR and I KM , significantly altered activation and inactivation characteristics of I Na , no significant alterations in protein or mRNA expression of sodium and M‐type potassium channels, along with higher AP amplitude and frequency and intracellular calcium concentrations. Most of these abnormalities were prevented by pretreatment with low‐ or high‐dose ticagrelor. Our data suggest that ticagrelor exerts cardioprotective effects, potentially through modulating the activity of different ion channels in SG neurons.
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Cheng et al. (2020) studied Myocardial infarction. Ticagrelor pretreatment vs. Control group was evaluated on Electrophysiological properties of stellate ganglion neurons (INa, IKDR, IKM, action potentials, intracellular calcium). Ticagrelor pretreatment prevented most abnormalities in sodium and potassium channel currents, action potentials, and intracellular calcium in stellate ganglion neurons following MI in rabbits.
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