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January 1, 2000Human Fertility

Hyperinsulinaemia and polycystic ovary syndrome

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Population

Women with polycystic ovary syndrome (PCOS)

Design

Review

Authors

GCGerard S. ConwayUniversity College London

Discussion

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Implication

Best long-term diabetes prevention in PCOS remains undefined; leaves open optimal strategies beyond short-term hyperinsulinaemia reduction.

Structured PICO

P
Population
Women with polycystic ovary syndrome (PCOS)
I
Intervention
Strategies to lower serum insulin concentrations including diet, exercise, and oral insulin sensitizing agents such as metformin

Hyperinsulinaemia is a fundamental disturbance in many women with PCOS, and while short-term efficacy of reducing it is clear, the best method to prevent progression to diabetes later in life remains undefined.

Cite This Study

Gerard S. Conway (2000) studied this question.

synapsesocial.com/papers/6a7da35cf9fad9e96bb86e3dhttps://doi.org/10.1080/1464727002000198761
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women<sup>1</sup>1999 · 1,539 citations
  2. 2Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome<sup>1</sup>1997 · 452 citations
  3. 3Role of Insulin Resistance in Human Disease1988 · 12,162 citations
  4. 4High Prevalence of Polycystic Ovaries and Associated Clinical, Endocrine, and Metabolic Features in Women with Previous Gestational Diabetes Mellitus1998 · 141 citations
  5. 5The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.1996 · 528 citations