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January 31, 2011Journal of Obstetrics and Gynaecology

Insulin resistance and the long-term consequences of polycystic ovary syndrome

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Key result

Insulin resistance in women with polycystic ovary syndrome increases the risk of gestational diabetes, type 2 diabetes, and cardiovascular disease in later life.

Population

Women with polycystic ovary syndrome (PCOS), particularly obese women with insulin resistance

Design

Review

Authors

RBR. K. BhathenaBombay Hospital

Discussion

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Implication

Heightens monitoring for metabolic risks in PCOS; leaves open whether interventions modify long-term cardiovascular outcomes.

Structured PICO

P
Population
Women with polycystic ovary syndrome (PCOS), particularly obese women with insulin resistance
E
Exposure
Lifestyle modification and insulin-sensitising drugs such as metformin

Women with PCOS and insulin resistance are at increased risk for long-term complications including type 2 diabetes and cardiovascular disease, which may be mitigated by lifestyle modification and metformin.

Cite This Study

R. K. Bhathena (2011) conducted a review in polycystic ovary syndrome. Insulin resistance was evaluated. Insulin resistance in women with polycystic ovary syndrome increases the risk of gestational diabetes, type 2 diabetes, and cardiovascular disease in later life.

synapsesocial.com/papers/6a884e7c8e586ad1c8a54f30https://doi.org/10.3109/01443615.2010.539722
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Also Consider

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  1. 1Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome.1996 · 428 citations
  2. 2Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)2001 · 26,202 citations
  3. 3Efficacy of the combination ethinyl oestradiol and cyproterone acetate on endocrine, clinical and ultrasonographic profile in polycystic ovarian syndrome2001 · 91 citations
  4. 4Dietary Composition in Restoring Reproductive and Metabolic Physiology in Overweight Women with Polycystic Ovary Syndrome2003 · 536 citations
  5. 5Metabolic features of the reproductive phenotypes of polycystic ovary syndrome2009 · 368 citations