Key result
Platelet reactivity monitoring has emerged as a strategy to address biological clopidogrel resistance and its association with thrombotic recurrence after percutaneous coronary intervention.
Why the study?
Does platelet reactivity monitoring improve outcomes in patients undergoing PCI on clopidogrel therapy?
Does platelet reactivity monitoring improve outcomes in patients undergoing PCI on clopidogrel therapy?
Platelet reactivity monitoring may help identify patients with biological clopidogrel resistance who are at higher risk for thrombotic recurrence after PCI.
May identify clopidogrel-resistant PCI patients at thrombotic risk; hypothesis-generating pending randomized outcome trials.
Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field.
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Bonello et al. (2009) conducted a review in Patients undergoing percutaneous coronary intervention (PCI). Platelet reactivity monitoring was evaluated on Major adverse cardiovascular events (MACE). Platelet reactivity monitoring has emerged as a strategy to address biological clopidogrel resistance and its association with thrombotic recurrence after percutaneous coronary intervention.
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