Population
Patients with acute myocardial infarction in England from 1981 to 2000
Design
Other
Follow-up
1981 to 2000
Key result
Thrombolytic agent usage in England took 8 years to reach the clinical need ceiling, resulting in an estimated shortfall of 167,800 doses (95% CI 94,000 to 241,700) over 14 years.
Authors
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Delayed thrombolytic uptake may indicate under-treatment in England; leaves open strategies to accelerate adoption of proven therapies.
Observational
Effect estimate: 167,800 doses (95% CI 94,000 to 241,700)
Despite rapid initial uptake, it took 8 years for thrombolysis usage to reach the clinical need ceiling in England, highlighting the need to monitor the adoption of cost-effective innovations.
Packer et al. (2004) conducted an observational in acute myocardial infarction. Thrombolytic agents vs. Estimated clinical need was evaluated on Shortfall in doses resulting from the difference between estimated ceiling of clinical need and doses purchased and provided (167,800 doses, 95% CI 94,000 to 241,700). Thrombolytic agent usage in England took 8 years to reach the clinical need ceiling, resulting in an estimated shortfall of 167,800 doses (95% CI 94,000 to 241,700) over 14 years.
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