Why the study?
Does mitral valve replacement with an aortic valve homograft improve clinical and hemodynamic outcomes in patients requiring mitral valve replacement?
Does mitral valve replacement with an aortic valve homograft improve clinical and hemodynamic outcomes in patients requiring mitral valve replacement?
Mitral valve replacement with an aortic valve homograft is feasible and shows early clinical improvement, though exercise-induced mitral insufficiency remains a concern.
Supports early symptom relief with homograft mitral replacement; leaves open durability and exercise hemodynamics.
Replacement of the mitral valve with an aortic valve homograft has become feasible. Clinical and hemodynamic assessments of eight patients who received the new homograft were made from 3 to 6 months following surgery. Marked improvement was reported by six patients and mild to moderate improvement by two. At rest the homografts functioned well, creating a trivial diastolic gradient between the left atrium and left ventricle and being mildly insufficient in two cases. On exercise there was moderate mitral insufficiency. Anticoagulants were used for 3 months following surgery and then discontinued. In 60 subsequent patient-months no thromboembolism has been observed. The data are as yet inconclusive, but the homograft shows promise of being a reasonable alternative to the prostheses currently in use.
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Gianelly et al. (1968) studied this question.
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