Key result
Pre-operative coronary artery revascularization did not significantly reduce the incidence of peri-operative myocardial infarction compared to no revascularization (24.2% vs. 28.6%; P=0.32).
Why the study?
Does a peri-operative myocardial infarction predict long-term mortality in patients with coronary artery disease undergoing elective vascular surgery?
Population
377 patients with documented coronary artery disease undergoing elective vascular surgery
Comparison
Peri-operative myocardial infarction vs No peri-operative myocardial infarction
Design
Cohort, Patients were originally part of a randomized trial, Blinded core lab…
Follow-up
2.5 years
Authors
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Pre-operative revascularization does not reduce peri-operative MI; leaves open whether preventing troponin elevation improves long-term survival after vascular surgery.
RCT (n=377)
Blinded
Randomized
Does a peri-operative myocardial infarction predict long-term mortality in patients with coronary artery disease undergoing elective vascular surgery?
Absolute Event Rate: 24.2% vs 28.6%
p-value: p=0.32
Peri-operative elevation in cardiac troponin I is common after elective vascular surgery and, particularly in diabetic patients, is a strong predictor of long-term mortality.
McFalls et al. (2008) conducted an RCT in Coronary artery disease (n=377). Coronary artery revascularization prior to vascular surgery vs. No pre-operative coronary revascularization was evaluated on Peri-operative myocardial infarction (p=0.32). Pre-operative coronary artery revascularization did not significantly reduce the incidence of peri-operative myocardial infarction compared to no revascularization (24.2% vs. 28.6%; P=0.32).
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