Visceral adiposity index was independently associated with cardiovascular events (OR 2.45; 95% CI 1.52-3.95; P<0.001) and cerebrovascular events (OR 1.63; 95% CI 1.06-2.50; P=0.025).
Observational (n=1,813)
Does the Visceral Adiposity Index (VAI) predict cardiovascular and cerebrovascular events better than classical risk factors in primary care patients?
The Visceral Adiposity Index is a novel, sex-specific indicator of visceral adipose function that strongly correlates with insulin sensitivity and independently predicts cardiovascular and cerebrovascular events.
Odds Ratio: 2.45 (95% CI 1.52–3.95)
p-value: p=<0.001
OBJECTIVE: To individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function. RESEARCH DESIGN AND METHODS: Visceral adiposity index (VAI) was first modeled on 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio- and cerebrovascular risk factors. RESULTS: All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (odd ratio OR 2.45; 95% CI 1.52-3.95; P < 0.001) and cerebrovascular (1.63; 1.06-2.50; P = 0.025) events. VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (R(s) = -0.721; P < 0.001). By contrast, no correlations were found for waist circumference and BMI. CONCLUSIONS: Our study suggests VAI is a valuable indicator of "visceral adipose function" and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.
Amato et al. (2010) conducted an observational in Cardiometabolic risk (n=1,813). Visceral adiposity index (VAI) vs. Classical cardio- and cerebrovascular risk factors was evaluated on Cardiovascular events (OR 2.45, 95% CI 1.52-3.95, p=<0.001). Visceral adiposity index was independently associated with cardiovascular events (OR 2.45; 95% CI 1.52-3.95; P<0.001) and cerebrovascular events (OR 1.63; 95% CI 1.06-2.50; P=0.025).
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