Key result
Diabetic patients with coronary heart disease had significantly lower serum adiponectin levels (3.96 vs 8.51 µg/ml) and higher insulin resistance and C-reactive protein levels compared to those without coronary heart disease.
Case-Control (n=72)
No
In patients with type 2 diabetes, elevated insulin resistance and CRP, along with decreased adiponectin, are strongly associated with the presence and severity of coronary artery disease.
Supports adiponectin as CHD marker in T2D; hypothesis-generating, requires prospective validation before any clinical use.
Relationship between insulin resistance, adiponectin and C-reactive protein and vascular endothelial injury in diabetic patients with coronary heart disease (CHD) was investigated. Clinical data of 72 patients with diabetes mellitus diagnosed in Weifang People's Hospital (Weifang, China) from October 2015 to January 2017 were retrospectively analyzed. Thirty patients were combined with CHD and 42 patients were not. There were 43 males and 29 females. General information and clinical data including age, sex, duration of diabetes mellitus, biochemical indicators, fasting insulin levels, CRP, insulin resistance index, arterial lesions of coronary angiography and Gensini scores were collected. The levels of FINS, FPG, HOMA-R and CPR were significantly higher, and the level of ADPN was significantly lower in diabetes complicated with CHD group than that without CHD group (P<0.05). Incidence of single coronary artery disease and mild coronary lesion were significantly lower, and incidences of double and triple lesions were significantly higher in diabetes complicated with CHD group than that without CHD group (P<0.05). Gensini score was significantly higher in diabetes complicated with CHD group than that without CHD group (P<0.05); Analysis of the correlation showed that CRP (r=0.422, P=0.001) and insulin resistance index (r=0.828, P=0.001) were positively correlated with Gensini score, while the adiponectin level was negatively correlated with Gensini score (r= -0.719, P<0.001). Logistic regression analysis showed that FINS, ADPN, HOMA-R, CPR, duration of diabetes mellitus and BMI had independently predictive value for diabetes complicated with CHD (P<0.05). Serum adiponectin, insulin resistance and CPR levels are closely related to diabetes mellitus combined with coronary heart disease, and can affect the degree of vascular endothelial injury in coronary heart disease.
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Xu et al. (2018) conducted a case-control in Type 2 diabetes mellitus with or without coronary heart disease (n=72). Coronary heart disease (CHD) vs. Diabetic patients without CHD was evaluated on Serum adiponectin (ADPN) level (µg/ml) (p=<0.001). Diabetic patients with coronary heart disease had significantly lower serum adiponectin levels (3.96 vs 8.51 µg/ml) and higher insulin resistance and C-reactive protein levels compared to those without coronary heart disease.
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