Key result
Elevated serum CRP levels were significantly associated with increased severity of coronary artery stenosis in diabetic patients undergoing angiography (p = 0.009).
Why the study?
Diabetes is a major risk factor for atherosclerosis and CRP is an independent CVD risk factor, prompting investigation into the relationship between serum CRP levels and coronary artery disease severity in diabetic patients.
Does serum CRP level correlate with the severity of coronary artery stenosis in diabetic patients?
Cross-Sectional (n=185)
No
Does serum CRP level correlate with the severity of coronary artery stenosis in diabetic patients?
p-value: p=0.009
Higher serum CRP levels and longer duration of diabetes are significantly associated with greater severity of coronary artery stenosis in diabetic patients.
CRP and diabetes duration associate with CAD severity in diabetics; hypothesis-generating, requiring prospective studies before any clinical application.
Background: Atherosclerosis is a disease characterized by the deposition of lipids on the inner walls of blood vessels. Diabetes is a significant risk factor for atherosclerosis. C-reactive protein (CRP) is a marker of systemic inflammation and an independent risk factor for cardiovascular diseases (CVD). This study aimed to investigate the relationship between serum CRP levels and the severity of coronary artery disease in diabetic patients. Materials and Methods: This descriptive-analytical study was conducted on 185 diabetic patients referred for coronary angiography based on non-invasive test indications. A checklist based on demographic information, blood pressure, and duration of diabetes was completed, and CRP testing was performed for each patient. Coronary angiographic data were also collected, including the type and severity of involved vessels reported by two cardiologists. Results: There was a significant relationship between serum CRP level and the severity of coronary artery disease (P-value=0.009). Additionally, there was a significant relationship between the duration of diabetes and the severity of coronary artery disease (P-value=0.006). Conclusion: We found a significant relationship between serum CRP levels and the severity of coronary artery stenosis and between the duration of diabetes and the severity of coronary artery stenosis.
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A 2025 study conducted a cross-sectional in Diabetes mellitus with suspected coronary artery disease (n=185). Serum CRP level was evaluated on Severity of coronary artery stenosis (p=0.009). Elevated serum CRP levels were significantly associated with increased severity of coronary artery stenosis in diabetic patients undergoing angiography (p = 0.009).
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