What question did this study set out to answer?

To determine whether potassium channel activation serves as a shared prejunctional mechanism through which multiple neuromodulators inhibit sensory nerves in the airways.

February 15, 1992Proceedings of the National Academy of SciencesOpen Access

Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.

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Authors

DSDavid StrettonThe University of Sydney MMM. MiuraToshiba (Japan)MBMG BelvisiAstraZeneca (United Kingdom)

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Implication

Preclinical study demonstrates that calcium-activated potassium channels mediate sensory nerve inhibition in guinea pig airways, highlighting targets for controlling neurogenic inflammation.

Key Points

To determine whether potassium channel activation serves as a shared prejunctional mechanism through which multiple neuromodulators inhibit sensory nerves in the airways.
Assessed the effects of selective potassium channel blockers on neuromodulator-mediated inhibition of excitatory nonadrenergic noncholinergic neural responses in guinea pig bronchi.
Tested charybdotoxin (10 nM), apamin (0.1 μM), and ATP-sensitive potassium channel blockers (BRL 31660 and glibenclamide, both 10 μM) against mu-opioid, neuropeptide Y, and alpha 2-adrenoceptor agonists.
Charybdotoxin (10 nM) completely blocked and reversed the inhibitory actions of mu-opioid, neuropeptide Y, and alpha 2-adrenoceptor agonists on excitatory sensory responses.
Inhibition was unaffected by the small-conductance calcium-activated potassium channel blocker apamin or by the ATP-sensitive potassium channel blockers BRL 31660 and glibenclamide.

Cite This Study

Stretton et al. (1992) studied this question.

synapsesocial.com/papers/6a7da842c108c8d3ff0452be https://doi.org/10.1073/pnas.89.4.1325

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Implication

Preclinical study demonstrates that calcium-activated potassium channels mediate sensory nerve inhibition in guinea pig airways, highlighting targets for controlling neurogenic inflammation.

Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.

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Implication

Key Points

Cite This Study

Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.

Discussion

Member takes

Implication

Key Points

Cite This Study

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