Population
Guinea-pig isolated trachealis (single smooth muscle cells and opened segments of trachea)
Design
Preclinical
Authors
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Findings in guinea-pig trachealis warrant no clinical change in bronchodilator therapy; leaves open BKCa role in human airway disease.
Charybdotoxin effectively inhibits large conductance K+-channels in guinea-pig trachealis, implicating these channels in the bronchodilator actions of isoprenaline and theophylline.
Murray et al. (1991) studied this question.
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