Key result
Potassium chloride acts directly on guinea-pig tracheal smooth muscle to induce spasm, which is associated with transient promotion of slow wave activity, graded depolarization, and cellular influx of extracellular calcium.
Population
Guinea-pigs of either sex, from which tracheae were excised for tissue bath and electrophysiological studies.
Comparison
Potassium chloride at 10-40 mmol/l added to the… vs Control tissues from the same trachea treated…
Design
Preclinical
Authors
Loading...
Animal data on KCl-induced tracheal spasm; leaves open translation to human airway disease or calcium-targeted therapies.
Potassium chloride induces spasm in guinea-pig trachealis through a direct action on smooth muscle cells, involving cellular influx of calcium linked to graded depolarization.
Foster et al. (1983) studied Normal guinea-pig trachealis (animal model). Potassium chloride (KCl) vs. Control conditions (normal Krebs solution, Ca2+-free Krebs, or vehicle) was evaluated on Spasmogenic action (tension development) and electrical activity. Potassium chloride acts directly on guinea-pig tracheal smooth muscle to induce spasm, which is associated with transient promotion of slow wave activity, graded depolarization, and cellular influx of extracellular calcium.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: