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August 1, 1992European Heart Journal

Myocardial protection during percutaneous transluminal coronary angioplasty: effects of trimetazidine*

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Why the study?

Does intracoronary trimetazidine reduce myocardial ischaemia during PTCA in patients undergoing left anterior descending coronary artery angioplasty?

Population

20 patients undergoing percutaneous transluminal coronary angioplasty of the left anterior descending…

Comparison

Trimetazidine 6 mg administered intracoronary 2… vs Placebo administered intracoronary (i.c.).

Design

RCT, randomized, double-blind, placebo-controlled

Follow-up

Acute (during PTCA procedure)

Authors

GKG. KoberTBTahisha M. BuckHSH. Sievert

Discussion

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Overview

Supports intracoronary trimetazidine to limit periprocedural ischemia in LAD PTCA; extends metabolic cytoprotection evidence to randomized PCI setting.

Structured PICO

Does intracoronary trimetazidine reduce myocardial ischaemia during PTCA in patients undergoing left anterior descending coronary artery angioplasty?

P
Population
20 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) of the left anterior descending coronary artery.
I
Intervention
Trimetazidine 6 mg administered intracoronary (i.c.) 2 minutes after a control balloon inflation.
C
Comparator
Placebo administered intracoronary (i.c.).
O
Outcome
Severity of myocardial ischaemia during PTCA, measured by maximum ST-segment shift, onset time of ischaemic signs, maximum T-wave changes, and area under the curve of i.c. ST-segment and T-wave changes during balloon inflation.surrogate

Intracoronary trimetazidine significantly reduces ECG signs of myocardial ischemia during balloon inflation in patients undergoing PTCA.

Cite This Study

Kober et al. (1992) studied this question.

synapsesocial.com/papers/6a7da910fd5c83ea4ea13f83https://doi.org/10.1093/oxfordjournals.eurheartj.a060322
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