Why the study?
Does a pre-procedural acute oral loading dose of trimetazidine reduce PCI-induced myocardial injury in patients with stable angina pectoris and single-vessel disease?
Does a pre-procedural acute oral loading dose of trimetazidine reduce PCI-induced myocardial injury in patients with stable angina pectoris and single-vessel disease?
A pre-procedural 60 mg oral loading dose of trimetazidine significantly reduces periprocedural myocardial injury, as measured by cTnI release, in patients undergoing PCI for stable angina.
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Pre-procedural TMZ may attenuate periprocedural injury in stable single-vessel PCI; leaves open whether this translates to clinical benefit in larger trials.
Bonello et al. (2007) studied this question.
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