Why the study?
Does pre-hemorrhagic use of SSRIs or statins increase the risk of vasospasm in patients with subarachnoid hemorrhage?
Population
514 patients with aneurysmal subarachnoid hemorrhage admitted between 1995 and 2003 who were evaluated for…
Comparison
Pre-hemorrhagic use of selective serotonin… vs No pre-hemorrhagic use of the respective…
Design
Cohort
Follow-up
Between days 4 and 14 post-admission
Authors
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SSRI and statin use was associated with higher vasospasm risk after SAH; hypothesis-generating and should not yet change practice.
Does pre-hemorrhagic use of SSRIs or statins increase the risk of vasospasm in patients with subarachnoid hemorrhage?
Pre-hemorrhagic use of SSRIs and statins is associated with a significantly increased risk of vasospasm following aneurysmal subarachnoid hemorrhage.
Singhal et al. (2005) studied this question.
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