Why the study?
Does apoA-I(Tangier) have abnormal metabolic characteristics compared to normal apoA-I in humans?
Population
32 subjects including 26 normal subjects, 3 Tangier disease heterozygotes, and 3 Tangier disease…
Comparison
Intravenous injection of radiolabeled normal and… vs Normal subjects vs Tangier heterozygotes vs…
Follow-up
7 to 21 days
Authors
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apoA-I(Tangier) shows accelerated catabolism; leaves open whether similar kinetics apply beyond Tangier disease or inform HDL-targeted therapies.
Does apoA-I(Tangier) have abnormal metabolic characteristics compared to normal apoA-I in humans?
Tangier disease is caused by a functionally and metabolically distinct abnormal apoA-I that leads to striking hypercatabolism of apoA-I and apoA-II.
Schaefer et al. (1982) studied this question.
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