Key result
Maternal immunization with inactivated EV71 vaccines at a dose of 162 U resulted in 96.2% to 97.0% survival in suckling pups following lethal EV71 challenge, compared to 3.7% in the control group.
Population
Female BALB/c mice (4-6 weeks old) and female ICR mice (9-10 weeks old) and their suckling pups
Comparison
Inactivated EV71 whole-virus vaccines from three… vs Corresponding diluent or aluminum salt adjuvant…
Design
Preclinical, Samples were blinded and distributed by lab 1 to the…
Follow-up
Up to 84 days post-inoculation for NAb; 14 days…
Authors
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Supports standardized EV71 vaccine evaluation in models; leaves open human maternal efficacy confirmation.
Absolute Event Rate: 96.2% vs 3.7%
Inactivated EV71 vaccines from three manufacturers demonstrated high immunogenicity and protective efficacy in a mouse model, providing a standardized basis for evaluating vaccine quality and predicting human efficacy.
Mao et al. (2012) studied Enterovirus 71 (EV71) infection. Inactivated EV71 vaccines (FCP-As) vs. Aluminum salt adjuvant (negative control) was evaluated on Survival rate of suckling mice after lethal EV71 challenge. Maternal immunization with inactivated EV71 vaccines at a dose of 162 U resulted in 96.2% to 97.0% survival in suckling pups following lethal EV71 challenge, compared to 3.7% in the control group.
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