Key result
Astragaloside IV at /kg/day attenuated the decline of fractional shortening and improved cardiac function in rats with congestive heart failure.
Why the study?
Does Astragaloside IV improve cardiovascular parameters in rats with congestive heart failure?
Does Astragaloside IV improve cardiovascular parameters in rats with congestive heart failure?
Astragaloside IV improves echocardiographic, hemodynamic, and histological parameters in a rat model of ischemic heart failure.
Answers are grounded in this paper and cite their sources.
No clinical implications from this rat study; hypothesis-generating for Astragaloside IV in HF models.
BACKGROUND: Astragaloside IV (ASI) in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats. METHODS: Using echocardiographic and haemodynamic measurements, we studied the effects of ASI on congestive heart failure (CHF) induced by ligation of the left coronary artery in rats. RESULTS: ASI (0.1, 0.3 and 1.0 mg/kg/day) attenuated the decline of fractional shortening (FS). The peak derivatives of the left ventricle (LV) pressure (dp/dt) in ASI-treated groups significantly increased. Both LV internal diameters in diastole (LVIDd) and in systole (LVIDs) decreased significantly after ASI treatment (0.3 and 1.0 mg/kg/day). ASI (1.0 mg/kg/day) attenuated the decrease of LV systolic pressure (LVSP). ASI treatment inhibited compensatory hypertrophy of myocardial cells and lowered the number of apoptotic myocytes. CONCLUSION: ASI improved cardiac functions as measured by cardiovascular parameters.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2009) studied Congestive heart failure (n=60). Astragaloside IV vs. Normal saline (Model group) was evaluated on Fractional shortening (FS) at 2 weeks (p=0.0028). Astragaloside IV at /kg/day attenuated the decline of fractional shortening and improved cardiac function in rats with congestive heart failure.
Synapse has enriched 10 related papers. Consider them for comparative context: