Why the study?
Astragaloside IV is widely used in cardiovascular disease treatment, but its antioxidative mechanism in heart failure required elucidation.
Does Astragaloside IV improve cardiac function and reduce infarct size in a rat model of heart failure?
Population
Sprague-Dawley rats with left coronary artery ligation (n = 15) and H9c2 cells
Comparison
Astragaloside IV (1 mg/kg/day) vs vehicle (saline)
Design
Animal and in vitro preclinical study
Follow-up
6 weeks
Authors
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Does not support clinical use; hypothesis-generating for Astragaloside IV in heart failure models.
Does Astragaloside IV improve cardiac function and reduce infarct size in a rat model of heart failure?
Astragaloside IV improves cardiac function and reduces infarct size in a rat model of heart failure by counteracting oxidative stress through the Nrf2/HO-1 pathway.
Sui et al. (2020) studied this question.
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