Population
Isolated hearts from guinea-pigs, rats, and domestic fowls maintained at constant temperature
Design
Preclinical
Authors
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Species-specific histamine effects on contractility limit animal-to-human translation; leaves open receptor profiling in human myocardium.
Histamine demonstrates species-dependent effects on cardiac contractility, increasing it in guinea pigs while decreasing it in rats and fowls.
A. L. Bartlet (1963) studied this question.