Key result
Combined chymase and ACE inhibition, relative to ACE inhibition alone, improved left ventricular function, decreased adverse cardiac remodeling, and improved survival after myocardial infarction in hamsters.
Why the study?
Does combined chymase and ACE inhibition improve cardiac remodeling and function compared to ACE inhibition alone in rodent models of myocardial infarction?
Population
Rodent models including wild-type and mast cell-deficient mice, and hamsters with induced myocardial…
Comparison
ACE inhibitor therapy alone or combined with… vs Vehicle control, or ACE inhibitor monotherapy.
Design
Preclinical
Follow-up
2 weeks (mice), 34 days (hamsters)
Authors
Loading...
Does not yet alter post-MI therapy; extends rodent evidence for combined chymase-ACE inhibition.
Does combined chymase and ACE inhibition improve cardiac remodeling and function compared to ACE inhibition alone in rodent models of myocardial infarction?
Effect estimate: 16% improvement in EF and 51% reduction in infarct area
p-value: p=<0.05
Mast cell chymase release during ACE inhibition maintains cardiac Ang II levels, and adding a chymase inhibitor to ACE inhibitor therapy improves post-MI cardiac remodeling and survival in rodents.
Wei et al. (2010) studied Myocardial Infarction and Heart Failure. Combined ACE inhibitor and chymase inhibitor therapy vs. Vehicle or ACE inhibitor monotherapy was evaluated on Left ventricular ejection fraction and infarct area (16% improvement in EF and 51% reduction in infarct area, p=<0.05). Combined chymase and ACE inhibition, relative to ACE inhibition alone, improved left ventricular function, decreased adverse cardiac remodeling, and improved survival after myocardial infarction in hamsters.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: